产品说明书
Paradol
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同义名 : | Paradol,帕多尔 ;[6]-Paradol;[6]-Gingerone;6-Paradol |
| CAS号 : | 27113-22-0 | |
| 货号 : | A357502 | |
| 分子式 : | C17H26O3 | |
| 纯度 : | 99%+ | |
| 分子量 : | 278.387 | |
| MDL号 : | MFCD01736103 | |
| 存储条件： |
粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 135 mg/mL(484.94 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Paradols are non-pungent and biotransformed metabolites of shogaols and reduce inflammatory responses as well as oxidative stress as shogaols. Pretreatment with 6-paradol (paradol derivatives) reduced neuroinflammatory responses in LPS-stimulated BV2 microglia by a concentration-dependent manner[3]. [6]-Paradol, a pungent phenolic compound present in certain Zingiberaceae plants, is known to have antimicrobial and analgesic activities. [6]-Paradol can attenuate promotion of skin carcinogenesis and TPA-induced ear edema in female ICR mice, and to induce apoptosis in cultured human promyelocytic leukemia (HL-60) cells[4]. Once-daily administration of 6-shogaol and 6-paradol (5 mg/kg/day, p.o.) to symptomatic EAE (experimental autoimmune encephalomyelitis) mice significantly alleviated clinical signs of the disease along with remyelination and reduced cell accumulation in the white matter of spinal cord[5]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.59mL 0.72mL 0.36mL |
17.96mL 3.59mL 1.80mL |
35.92mL 7.18mL 3.59mL |
| 参考文献 |
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