产品说明书

AZ876

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Chemical Structure| 898800-26-5 同义名 : -
CAS号 : 898800-26-5
货号 : A349245
分子式 : C24H29N3O3S
纯度 : 99%+
分子量 : 439.57
MDL号 : MFCD30377191
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(238.87 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 AZ876 stands out as a highly effective and selective LXR agonist, exhibiting substantially greater potency than GW3965 on both human LXRα and LXRβ, by 25-fold and 2.5-fold respectively. This suggests its potential in modulating lipid metabolism and inflammatory processes through LXR pathway activation[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.27mL

0.45mL

0.23mL

11.37mL

2.27mL

1.14mL

22.75mL

4.55mL

2.27mL
参考文献

[1]Cannon MV et al. The liver X receptor agonist AZ876 protects against pathological cardiac hypertrophy and fibrosis without lipogenic side effects. Eur J Heart Fail. 2015 Mar;17(3):273-82.

[2]van der Hoorn J et al. Low dose of the liver X receptor agonist, AZ876, reduces atherosclerosis in APOE*3Leiden mice without affecting liver or plasma triglyceride levels. Br J Pharmacol. 2011 Apr;162(7):1553-63.