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Tetracycline HCl

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Chemical Structure| 64-75-5 同义名 : Tetracycline (hydrochloride);NCI-c55561;Tetracycline HCl
CAS号 : 64-75-5
货号 : A328003
分子式 : C22H25ClN2O8
纯度 : 98%
分子量 : 480.9
MDL号 : MFCD00078142
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(124.77 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(103.97 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Tetracycline (hydrochloride) is a broad-spectrum antibiotic, exhibiting activity against a wide range of gram-positive and gram-negative bacteria. The obtained lifetime for pheophytin formed during chlorophyll reaction - with tetracycline hydrochloride was τ = 5.71 ± 0.02 ns. The experiment demonstrated two mechanisms of chlorophyll degradation to pheophytin by tetracycline hydrochloride, i.e. 1) loss of Mg2+ ions from the chlorophyll molecule as a result of the presence of H+ ions in solution (i.e. as a result of medium acidification), and 2) removal of Mg2+ ions directly from chlorophyll by tetracycline which binds Mg2+ ions from the chlorophyll[3]. Moreover, polyethyleneimine (PEI) modified GO as a tetracycline hydrochloride (TCH) carrier and release platform was constructed (pGO-TCH), pGO-TCH nanostructures exhibit good antibacterial behavior[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.08mL

0.42mL

0.21mL

10.40mL

2.08mL

1.04mL

20.79mL

4.16mL

2.08mL
参考文献

[1]Buck MA, Cooperman BS. Single protein omission reconstitution studies of tetracycline binding to the 30S subunit of Escherichia coli ribosomes. Biochemistry. 1990 Jun 5;29(22):5374-9.

[2]Chopra I, Roberts M. Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. Microbiol Mol Biol Rev. 2001 Jun;65(2):232-60 ; second page, table of contents.

[3]Rydzyński D, Piotrowicz-Cieślak AI, Grajek H, Wasilewski J. Investigation of chlorophyll degradation by tetracycline. Chemosphere. 2019;229:409–417

[4]Jiang L, Su C, Ye S, et al. Synergistic antibacterial effect of tetracycline hydrochloride loaded functionalized graphene oxide nanostructures. Nanotechnology. 2018;29(50):505102