产品说明书
PF-431396
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同义名 : | - |
| CAS号 : | 717906-29-1 | |
| 货号 : | A325541 | |
| 分子式 : | C22H21F3N6O3S | |
| 纯度 : | 99%+ | |
| 分子量 : | 506.501 | |
| MDL号 : | MFCD16038300 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 靶点 |
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| 描述 | PYK2 (proline-rich tyrosine kinase 2) and Pyk2 (proline-rich tyrosine kinase 2) are non-receptor protein tyrosine kinases that are involved in cell proliferation, migration and survival. PF-431396 is a dual inhibitor of both PYK2 and FAK with IC50 values of 11nM and 2nM, respectively. Treatment with PF-431396 ranging in 0.1-1μM on hMSC led to a modest albeit significant increase in day 7 alkaline phosphatase activity[1]. Suppression of Pyk2 and FAK by PF-431396 at concentration of 2.5μM to A20 cells can inhibit B cell spreading induced by BCR/integrin co-stimulation or integrin engagement[2]. | ||
| 作用机制 | PF-431396 is an ATP-competitive inhibitor of FAK kinases which can occupy the nucleotide binding pocket, with the pyrimidine ring located in the adenine pocket.[1] | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.97mL 0.39mL 0.20mL |
9.87mL 1.97mL 0.99mL |
19.74mL 3.95mL 1.97mL |
