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Frentizole

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Chemical Structure| 26130-02-9 同义名 : Frentizol
CAS号 : 26130-02-9
货号 : A320901
分子式 : C15H13N3O2S
纯度 : 99%+
分子量 : 299.348
MDL号 : MFCD00030234
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 12 mg/mL(40.09 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Frentizole is an immunosuppressant approved by the FDA and inhibits the interaction between Aβ and ABAD with an IC50 of 200 µM, finding use in research on rheumatoid arthritis and systemic lupus erythematosus[1].[2].[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.34mL

0.67mL

0.33mL

16.70mL

3.34mL

1.67mL

33.41mL

6.68mL

3.34mL
参考文献

[1]Meisel AD, et al. Effect of frentizole on mitogen-induced blastogenesis in human lymphocytes. J Immunopharmacol. 1979;1(4):483-95.

[2]Walker SE, et al. Prolonged lifespans in female NZB/NZW mice treated with the experimental immunoregulatory drug frentizole. Arthritis Rheum. 1982 Nov;25(11):1291-7.

[3]Yuli Xie, et al. Identification of small-molecule inhibitors of the Abeta-ABAD interaction. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4657-60.