Moxonidine HCl

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Chemical Structure| 75536-04-8 同义名 : BDF5895 hydrochloride;Moxonidine hydrochloride
CAS号 : 75536-04-8
货号 : A316775
分子式 : C9H13Cl2N5O
纯度 : 98+%
分子量 : 278.138
MDL号 : MFCD06795643
存储条件：

Pure form

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(377.51 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Moxonidine hydrochloride is a selective agonist at the imidazoline receptor subtype 1, used as antihypertensive agent.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.60mL

0.72mL

0.36mL

17.98mL

3.60mL

1.80mL

35.95mL

7.19mL

3.60mL
参考文献

[1]Chan CK, Burke SL, et al. Imidazoline receptors associated with noradrenergic terminals in the rostral ventrolateral medulla mediate the hypotensive responses of moxonidine but not clonidine. Neuroscience.

[2]Schafer U, Burgdorf C, et al. Presynaptic effects of moxonidine in isolated buffer perfused rat hearts: role of imidazoline-1 receptors and alpha2-adrenoceptors. J Pharmacol Exp Ther. 2002 Dec;303(3):1163-70.