产品说明书
Ac-CoA Synthase Inhibitor1
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同义名 : | Acetyl-CoA Synthase Inhibitor;ACSS2 inhibitor;Ac-CoA Synthase Inhibitor I;ACSS-1;VY-3-249;MDK6149;ACCS2 Inhibitor |
| CAS号 : | 508186-14-9 | |
| 货号 : | A314446 | |
| 分子式 : | C20H18N4O2S2 | |
| 纯度 : | 96% | |
| 分子量 : | 410.512 | |
| MDL号 : | MFCD03232237 | |
| 存储条件： |
粉末 Keep in dark place,Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 30 mg/mL(73.08 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Acetyl-CoA represents a central node of carbon metabolism that plays a key role in bioenergetics, cell proliferation and the regulation of gene expression. The nucleocytosolic acetyl-CoA synthetase enzyme, ACSS2, supplies a key source of acetyl-CoA for tumors by capturing acetate as a carbon source[1]. ACSS2 inhibitor (quinoxaline) is a reversible inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2) with IC50 of ~ 600 nM. This quinoxaline compound inhibits the ability of HepG2 cells to incorporate [14C]acetate into lipids with IC50 of 6.8 μM, and also inhibits HepG2 utilization of [14C]acetate for histone acetylation with IC50 of 5.5 μM[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.44mL 0.49mL 0.24mL |
12.18mL 2.44mL 1.22mL |
24.36mL 4.87mL 2.44mL |
| 参考文献 |
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