Pipemidic acid

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Chemical Structure| 51940-44-4 同义名 : Acido pipemidico
CAS号 : 51940-44-4
货号 : A311707
分子式 : C14H17N5O3
纯度 : 98%
分子量 : 303.317
MDL号 : MFCD00057291
存储条件:

Pure form Keep in dark place,Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 4 mg/mL(13.19 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

1M NaOH: 100 mg/mL(329.69 mM),配合低频超声,并调节pH至11

动物实验配方:
生物活性
描述 Pipemidic acid, a derivative of piromidic acid, is an antibacterial agent that targets DNA gyrase. It is effective against gram-negative bacteria, including Pseudomonas aeruginosa, and some gram-positive bacteria, making it applicable in researching intestinal, urinary, and biliary tract infections[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.30mL

0.66mL

0.33mL

16.48mL

3.30mL

1.65mL

32.97mL

6.59mL

3.30mL

参考文献

[1]Iacovino R, et al. β-Cyclodextrin inclusion complex to improve physicochemical properties of pipemidic acid: characterization and bioactivity evaluation. Int J Mol Sci. 2013 Jun 25;14(7):13022-41.

[2]Aoyama H, et, al. Purification of Citrobacter freundii DNA gyrase and inhibition by quinolones. Antimicrob Agents Chemother. 1988 Jan;32(1):104-9.

[3]Shimizu M, et, al. Pipemidic acid: absorption, distribution, and excretion. Antimicrob Agents Chemother. 1975 Apr;7(4):441-6.