Ampicillin Sodium

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Chemical Structure| 69-52-3 同义名 : 氨苄青霉素钠 ;D-(-)-α-Aminobenzylpenicillin sodium salt; Ampicillin(sodium salt)
CAS号 : 69-52-3
货号 : A307483
分子式 : C16H18N3NaO4S
纯度 : 98%
分子量 : 371.387
MDL号 : MFCD00064313
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 190 mg/mL(511.6 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 200 mg/mL(538.52 mM)
动物实验配方：
生物活性
描述 Ampicillin sodium is a member of β-lactam antibiotics (BLAs) used in treating a wide range of diseases and infections which were caused by both gram-positive and gram-negative bacteria in humans and animals, such as infections by sensitive bacteria, gastrointestinal and urinary tract infections, meningitis, and septicemia[3]. Ampicillin can dose-dependently protects neurons against ischemic brain injury[4]. In addition, hydrophilic ampicillin sodium can be developed as a transdermal delivery system with SA (sodium alginate) that is an alternative to intravenous administration and has minimal adverse effects[5].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01892488 Chronic Obstructive Pulmonary ... 展开 >>Disease (COPD) 收起 << Phase 4 Recruiting September 2018 Germany ... 展开 >> Universitätsklinikum Aachen Recruiting Aachen, Germany HELIOS Klinikum Emil von Behring Berlin Recruiting Berlin, Germany Universitätsklinikum Dresden Recruiting Dresden, Germany Universitätsmedizin Greifswald Recruiting Greifswald, Germany Medizinische Hochschule Hannover Recruiting Hannover, Germany Principal Investigator: Tobias Welte, Prof. Dr.          Lungenfachklinik Immenhausen Recruiting Immenhausen, Germany Universitätsklinikum Jena Recruiting Jena, Germany Universitätsklinikum Schleswig-Holstein Campus Lübeck Recruiting Lübeck, Germany Brüderkrankenhaus St. Josef Paderborn Recruiting Paderborn, Germany Diakoniekrankenhaus Rotenburg Recruiting Rotenburg, Germany Krankenhaus Bethanien Solingen Recruiting Solingen, Germany 收起 <<
NCT01975493 - Active, not recruiting June 2018 United Kingdom ... 展开 >> Royal Cornwall Hospitals NHS Trust Truro, Cornwall, United Kingdom, TR1 3LJ Taunton and Somerset NHS Foundation Trust Taunton, Somerset, United Kingdom, TA1 5DA University Hospitals Coventry and Warwickshire NHS Trust Coventry, United Kingdom, CV2 2DX Alder Hey Children's Hospital Liverpool, United Kingdom, L12 2AP Liverpool Women's Hospital Liverpool, United Kingdom, L8 7SS St George's Hospital London, United Kingdom, SW17 0QT Great Ormond Street Hospital London, United Kingdom, WC1N 3JH John Radcliffe Hospital Oxford, United Kingdom, OX3 9DU Queen Alexandra Hospital Portsmouth, United Kingdom, PO6 3LY 收起 <<
NCT03113344 - Recruiting December 31, 2025 China ... 展开 >> Beijing Children's Hospital of Capital Medical University Recruiting Beijing, China Contact: Adong Shen, Master    13370115087    shenad16@hotmail.com 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.69mL

0.54mL

0.27mL

13.46mL

2.69mL

1.35mL

26.93mL

5.39mL

2.69mL
参考文献

[1]Lee KE, Cho KO, et al. The neuroprotective mechanism of ampicillin in a mouse model of transient forebrain ischemia. Korean J Physiol Pharmacol. 2016 Mar;20(2):185-92.

[2]Chopra SL, Dale DG, et al. Effect of Ampicillin on E. Coli of Swine Origin. Can J Comp Med Vet Sci. 1963 Sep;27(9):223-7.

[3]Wu N, Luo Z, Ge Y, Guo P, Du K, Tang W, Du W, Zeng A, Chang C, Fu Q. A novel surface molecularly imprinted polymer as the solid-phase extraction adsorbent for the selective determination of ampicillin sodium in milk and blood samples. J Pharm Anal. 2016 Jun;6(3):157-164.

[4]Lee KE, Cho KO, Choi YS, Kim SY. The neuroprotective mechanism of ampicillin in a mouse model of transient forebrain ischemia. Korean J Physiol Pharmacol. 2016 Mar;20(2):185-92.

[5]Bagyalakshmi J, Vamsikrishna RP, Manavalan R, Ravi TK, Manna PK. Formulation development and in vitro and in vivo evaluation of membrane-moderated transdermal systems of ampicillin sodium in ethanol: pH 4.7 buffer solvent system. AAPS PharmSciTech. 2007 Jan 26;8(1):7.