Prothionamide

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Chemical Structure| 14222-60-7 同义名 : 2-丙基吡啶-4-硫代甲酰胺 ;Protionamide;Tebeform;2-Propyl-4-thiocarbamoylpyridine;2-Propyl-4-pyridinecarbothioamide;1321-TH
CAS号 : 14222-60-7
货号 : A306379
分子式 : C9H12N2S
纯度 : 98%
分子量 : 180.27
MDL号 : MFCD00464119
存储条件:

Pure form Inert atmosphere,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(582.46 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 Protionamide is a drug used in the treatment of tuberculosis and has also been tested for use in the treatment of leprosy.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03237182 Tuberculosis, Multidrug-Resist... 展开 >>ant 收起 << Phase 4 Recruiting December 2021 South Africa ... 展开 >> King Dinuzulu Hospital Recruiting Durban, Kwa-Zulu Natal, South Africa Contact: Nesri Padayatchi, MBcHB    0312604550    nesri.padayatchi@caprisa.org    Contact: Resha Boodhram, BTech    0828383651    resha.boodhram@caprisa.org 收起 <<
NCT00042289 HIV Infections Phase 4 Recruiting September 30, 2019 -
NCT00513396 Tuberculosis, Multidrug-Resist... 展开 >>ant 收起 << Phase 2 Phase 3 Completed - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.55mL

1.11mL

0.55mL

27.74mL

5.55mL

2.77mL

55.47mL

11.09mL

5.55mL

参考文献

[1]Wang F, Langley R, et al. Mechanism of thioamide drug action against tuberculosis and leprosy. J Exp Med. 2007 Jan 22;204(1):73-8.

[2]Fajardo TT, Guinto RS, et al. A clinical trial of ethionamide and prothionamide for treatment of lepromatous leprosy. Am J Trop Med Hyg. 2006 Mar;74(3):457-61.