产品说明书

Pinostrobin

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Chemical Structure| 480-37-5 同义名 : -
CAS号 : 480-37-5
货号 : A305777
分子式 : C16H14O4
纯度 : 98+%
分子量 : 270.28
MDL号 : MFCD06858342
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(388.49 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Pinostrobin, a natural product isolated and purified from the herbs of Cajanus cajan with anti-inflammatory, cytotoxic, anti-hemorrhagic and analgesic activities, exerts a neuroprotective effect against Aβ(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage and calcium overload, as well as suppressing the mitochondrial pathway of cellular apoptosis, and can inhibit HSV-1 replication with 50% effective concentration (EC(50)) of 22.71 ± 1.72 ug/mL.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.70mL

0.74mL

0.37mL

18.50mL

3.70mL

1.85mL

37.00mL

7.40mL

3.70mL
参考文献

[1]Gomez-Betancur I, Benjumea D, et al. Inhibition of the toxic effects of Bothrops asper venom by pinostrobin, a flavanone isolated from Renealmia alpinia (Rottb.) MAAS. J Ethnopharmacol. 2014 Sep 29;155(3):1609-15.

[2]Patel NK, Bhutani KK. Pinostrobin and Cajanus lactone isolated from Cajanus cajan (L.) leaves inhibits TNF-α and IL-1β production: in vitro and in vivo experimentation. Phytomedicine. 2014 Jun 15;21(7):946-53.