Herbacetin

产品说明书

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Chemical Structure| 527-95-7 同义名 : Isoarticulatidin;3,5,7,8,4'-Pentahydroxyflavone;8-hydroxy Kaempferol
CAS号 : 527-95-7
货号 : A305232
分子式 : C15H10O7
纯度 : 99%+
分子量 : 302.236
MDL号 : N/A
存储条件:

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(347.41 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 Herbacetin, a natural product isolated and purified from the herbs of Equisetum hyemale L., induces HepG2 apoptosis in a ROS-mediated mitochondria-dependent manner that correlate with the inactivation of the PI3K/Akt pathway, exerts an anti-inflammatory effect through suppression of LPS-induced JNK and NF-κB signaling pathways and diminished production of proinflammatory cytokines and mediators, and is a Met inhibitor with a potential utility in cancer therapeutics, suppresses the HGF-induced motility of human breast cancer MDA-MB-231 cells by inhibiting c-Met and Akt phosphorylation.
4. Herbacetin
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.31mL

0.66mL

0.33mL

16.54mL

3.31mL

1.65mL

33.09mL

6.62mL

3.31mL

参考文献

[1]Li L, Sapkota M, et al. Herbacetin inhibits inducible nitric oxide synthase via JNK and nuclear factor-κB in LPS-stimulated RAW264.7 cells. Eur J Pharmacol. 2015 Oct 15;765:115-23.

[2]Hyuga S, Hyuga M, et al. Herbacetin, a constituent of ephedrae herba, suppresses the HGF-induced motility of human breast cancer MDA-MB-231 cells by inhibiting c-Met and Akt phosphorylation. Planta Med. 2013 Nov;79(16):1525-30.