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ZL006

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Chemical Structure| 1181226-02-7 同义名 : -
CAS号 : 1181226-02-7
货号 : A301812
分子式 : C14H11Cl2NO4
纯度 : 99%+
分子量 : 328.147
MDL号 : MFCD20527326
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(76.19 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 ZL006 exhibits minimal cytotoxicity, with no observed growth inhibition of BCECs at concentrations ranging from 0.001 to 10 μg/mL. However, the cytotoxic effect of T7-P-LPs/ZL006 is significantly increased at a concentration of 10 μg/mL. The uptake of ZL006-loaded P-LPs and T7-P-LPs by BCECs is evident after 0.5 hours of incubation at concentrations between 100 μg/mL and 600 μg/mL[1]. ZL006 does not interfere with the interaction between nNOS-PDZ and PSD-95-PDZ, nor does it disturb the nNOS β-finger structure[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.05mL

0.61mL

0.30mL

15.24mL

3.05mL

1.52mL

30.47mL

6.09mL

3.05mL
参考文献

[1]Wang Z, et al. Enhanced anti-ischemic stroke of ZL006 by T7-conjugated PEGylated liposomes drug delivery system. Sci Rep. 2015 Jul 29;5:12651.

[2]Bach A, et al. Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions. Sci Rep. 2015 Jul 16;5:12157.