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KHK-IN-1 HCl

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Chemical Structure| 1303470-48-5 同义名 : KHK-IN-1 hydrochloride
CAS号 : 1303470-48-5
货号 : A299396
分子式 : C21H27ClN8S
纯度 : 98%+
分子量 : 459.011
MDL号 : MFCD29472233
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(54.46 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 14 mg/mL(30.5 mM)，配合低频超声，并水浴加热至45℃助溶
动物实验配方：
生物活性
描述 KHK-IN-1 hydrochloride is a specific and cell-permeable inhibitor of ketohexokinase (KHK) (IC50=12 nM; F=34%). It effectively suppresses the generation of F1P in HepG2 cell lysates with an IC50 greater than 400 nM. KHK-IN-1 hydrochloride holds promise for research in the fields of diabetes and obesity[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.18mL

0.44mL

0.22mL

10.89mL

2.18mL

1.09mL

21.79mL

4.36mL

2.18mL
参考文献

[1]Maryanoff BE, et al. Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site. ACS Med Chem Lett. 2011 Apr 18;2(7):538-43.