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Pimethixene maleate

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Chemical Structure| 13187-06-9 同义名 : Pimetixene maleate
CAS号 : 13187-06-9
货号 : A293853
分子式 : C23H23NO4S
纯度 : 97%
分子量 : 409.498
MDL号 : MFCD00079242
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(256.41 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • D4 receptor

    Dopamine D4.4 Receptor, pKi:7.54

  • D1 receptor

    Dopamine D1 Receptor, pKi:6.37

  • D2 receptor

    Dopamine D2 Receptor, pKi:8.19
描述 Similarly, Pimethixene maleate acts as both an antihistamine and an antiserotonergic compound, also used for migraine prevention. It antagonizes the same receptors as Pimethixene with identical potency and binding affinities[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.44mL

0.49mL

0.24mL

12.21mL

2.44mL

1.22mL

24.42mL

4.88mL

2.44mL
参考文献

[1]Schmitz B, et al. BF-1--a novel selective 5-HT2B receptor antagonist blocking neurogenic dural plasma protein extravasation in guinea pigs. Eur J Pharmacol. 2015 Mar 15;751:73-80.