产品说明书

Sulfaguanidine

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Chemical Structure| 57-67-0 同义名 : 磺胺胍
CAS号 : 57-67-0
货号 : A293011
分子式 : C7H10N4O2S
纯度 : 98% (<8%H2O)
分子量 : 214.245
MDL号 : MFCD00038136
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(490.09 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 3 mg/mL(14 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Sulfaguanidine (SG), belongs to the class of sulfonamide drug used as an effective antibiotic. Cocrystal SG-TBA showed better antibacterial activity and reduced hemolysis, thereby, reduced cytotoxicity than SG-PT (SG were synthesized with thiobarbutaric acid and 1,10-phenanthroline)[2]. Neonatal rats displayed a lower elimination of sulfaguanidine than adult rats. Sulfaguanidine was poorly absorbed by adult rats, but was efficiently absorbed by immature gastrointestines of neonatal rats[3]. Moreover, the sulfaguanidine must be added to the list of drug-induced fixed drug eruptions with limited absorption from the gastrointestinal tract[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.67mL

0.93mL

0.47mL

23.34mL

4.67mL

2.33mL

46.68mL

9.34mL

4.67mL
参考文献

[1]Mizuno N, Nishikata M, et al. Gastrointestinal absorption of sulfaguanidine in neonatal and adult rats. J Pharmacobiodyn. 1986 Oct;9(10):787-92.

[2]Abidi SSA, Azim Y, Khan SN, Khan AU. Sulfaguanidine cocrystals: Synthesis, structural characterization and their antibacterial and hemolytic analysis. J Pharm Biomed Anal. 2018;149:351–357

[3]Mizuno N, Nishikata M, Morita E, Miyake K. Gastrointestinal absorption of sulfaguanidine in neonatal and adult rats. J Pharmacobiodyn. 1986;9(10):787–792

[4]Kastalli S, El Aidli S, Daghfous R, et al. Erythème pigmenté fixe à la sulfaguanidine [Fixed drug eruption induced by sulfaguanidine]. Ann Dermatol Venereol. 2004;131(4):382–384