产品说明书

Indinavir sulfate

Print
Chemical Structure| 157810-81-6 同义名 : MK-639;L735524;Indinavir (sulfate);Crixivan
CAS号 : 157810-81-6
货号 : A290622
分子式 : C36H49N5O8S
纯度 : 98+%
分子量 : 711.868
MDL号 : MFCD00920346
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(147.5 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(70.24 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Indinavir sulfate is a potent and specific HIV protease inhibitor that appears to have good oral bioavailability.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00002440 HIV Infections Phase 2 Completed - United States, California ... 展开 >> UCSD Treatment Ctr San Diego, California, United States, 921036329 United States, Connecticut Yale U / New Haven Med Ctr / AIDS Clinical Trials Unit New Haven, Connecticut, United States, 065102483 United States, Missouri Kansas City AIDS Research Consortium Kansas City, Missouri, United States, 64111 United States, New York NYU Med Ctr / Dept of Medicine / AIDS Clinical Trial New York, New York, United States, 10016 United States, North Carolina Carolinas Med Ctr Charlotte, North Carolina, United States, 28232 United States, Ohio Case Western Reserve Univ / AIDS Clinical Trials Unit Cleveland, Ohio, United States, 44106 United States, Pennsylvania Univ of Pittsburgh Med Ctr Pittsburgh, Pennsylvania, United States, 15213 United States, Tennessee Vanderbilt Univ Med Ctr Nashville, Tennessee, United States, 372321302 收起 <<
NCT00006154 HIV Infections Phase 3 Completed - Canada, British Columbia ... 展开 >> Viridae Clinical Sciences / University of British Columbia Vancouver, British Columbia, Canada Canada, Quebec Centre de traitment d'immunodeficience Montreal, Quebec, Canada Centre Hospitalier de la Universite de Montreal (CHUM) Montreal, Quebec, Canada Institut Thoracique de Montreal Montreal, Quebec, Canada 收起 <<
NCT00000923 HIV Infections Not Applicable Completed - United States, Alabama ... 展开 >> Alabama Therapeutics CRS Birmingham, Alabama, United States, 35294 United States, California USC CRS Los Angeles, California, United States, 900331079 Harbor-UCLA Med. Ctr. CRS Torrance, California, United States, 90502 United States, Hawaii Univ. of Hawaii at Manoa, Leahi Hosp. Honolulu, Hawaii, United States, 96816 United States, Iowa Univ. of Iowa Healthcare, Div. of Infectious Diseases Iowa City, Iowa, United States, 52242 United States, Louisiana Tulane Univ. A1701 CRS New Orleans, Louisiana, United States, 70112 United States, Missouri St. Louis ConnectCare, Infectious Diseases Clinic St Louis, Missouri, United States, 63112 Washington U CRS St. Louis, Missouri, United States United States, New York Mt. Sinai Med. Ctr. A0404 CRS New York, New York, United States, 10029 United States, Ohio Case CRS Cleveland, Ohio, United States, 44106 The Ohio State Univ. AIDS CRS Columbus, Ohio, United States, 432101228 United States, Washington University of Washington AIDS CRS Seattle, Washington, United States, 98104 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.40mL

0.28mL

0.14mL

7.02mL

1.40mL

0.70mL

14.05mL

2.81mL

1.40mL
参考文献

[1]Liu F, Boross PI, et al. Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S. J Mol Biol. 2005 Dec 9;354(4):789-800.

[2]Stein DS, Fish DG, et al. A 24-week open-label phase I/II evaluation of the HIV protease inhibitor MK-639(indinavir). AIDS. 1996 May;10(5):485-92.