产品说明书

FEN1-IN-4

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Chemical Structure| 1995893-58-7 同义名 : FEN1 Inhibitor C2;JUN93587
CAS号 : 1995893-58-7
货号 : A288260
分子式 : C12H12N2O3
纯度 : 99%+
分子量 : 232.235
MDL号 : MFCD31812378
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(516.72 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Human flap endonuclease-1 (hFEN1) is a structure-selective metallonuclease that plays a key role in DNA replication and repair, and may be used as an oncology target. FEN1 inhibitor C2 inhibits hFEN1-336Δ with an IC50 value of 30.0±6.0nM[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.31mL

0.86mL

0.43mL

21.53mL

4.31mL

2.15mL

43.06mL

8.61mL

4.31mL
参考文献

[1]Ward TA, McHugh PJ, Durant ST. Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes. PLoS One. 2017 Jun 19;12(6):e0179278.

[2]Exell JC, Thompson MJ, Finger LD, et al. Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site. Nat Chem Biol. 2016;12(10):815-821.