(R)-(-)-Ibuprofen

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Chemical Structure| 51146-57-7 同义名 : (-)-Ibuprofen;(R)-Ibuprofen;Levibuprofen;l-Ibuprofen
CAS号 : 51146-57-7
货号 : A275175
分子式 : C13H18O2
纯度 : 96%
分子量 : 206.281
MDL号 : MFCD00069290
存储条件：

Pure form Sealed in dry,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(509.01 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 (R)-(-)-Ibuprofen, the R-enantiomer of ibuprofen, does not inhibit cyclooxygenase (COX) enzymes but participates in lipid metabolism pathways and is incorporated into triglycerides alongside endogenous fatty acids[1]. At a concentration of 1 μM, (R)-(-)-Ibuprofen significantly reduces NF-κB activation and fully prevents its induction at 10 μM. However, it inhibits NF-κB luciferase activity with an IC50 of 121.8 μM, which is less effective compared to the S(+)-enantiomer of ibuprofen (IC50 of 61.7 μM). Additionally, (R)-(-)-Ibuprofen at 10 mM does not affect the heat shock factor (HSF)[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.85mL

0.97mL

0.48mL

24.24mL

4.85mL

2.42mL

48.48mL

9.70mL

4.85mL
参考文献

[1]Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14.

[2]Scheuren N, et al. Modulation of transcription factor NF-kappaB by enantiomers of the nonsteroidal drug ibuprofen. Br J Pharmacol. 1998 Feb;123(4):645-52.