产品说明书

BMS-202

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Chemical Structure| 1675203-84-5 同义名 : Programmed Cell Death 1/Programmed Cell Death-Ligand 1 Inhibitor 2;PD-1/PD-L1 inhibitor 2
CAS号 : 1675203-84-5
货号 : A257865
分子式 : C25H29N3O3
纯度 : 99%+
分子量 : 419.516
MDL号 : MFCD29905455
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(250.29 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • PD-1/PD-L1 interaction

    PD-1/PD-L1 interaction, IC50:0.018 μM
描述 BMS-202 is identified as a potent and nonpeptidic inhibitor of the PD-1/PD-L1 complex, demonstrating an IC50 of 18 nM and a KD of 8 μM. It binds to PD-L1, effectively preventing the interaction between human PD-1 and PD-L1, and exhibits antitumor capabilities[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.38mL

0.48mL

0.24mL

11.92mL

2.38mL

1.19mL

23.84mL

4.77mL

2.38mL
参考文献

[1]Zak KM, et al. Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1). Oncotarget. 2016 May 24;7(21):30323-35.

[2]Ashizawa T, et al. Antitumor activity of the PD-1/PD-L1 binding inhibitor BMS-202 in the humanized MHC-double knockout NOG mouse. Biomed Res. 2019;40(6):243-250.