产品说明书

D-Sorbitol

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Chemical Structure| 50-70-4 同义名 : 山梨醇 ;Sorbitol;D-Glucitol;Glucitol
CAS号 : 50-70-4
货号 : A256763
分子式 : C6H14O6
纯度 : 95%
分子量 : 182.172
MDL号 : MFCD00004708
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(576.38 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(548.93 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary supplement. In oral liquids, D-Sorbitol (Sorbitol) is used as a sugar substitute and as a drug stabilizer. D-Sorbitol (Sorbitol) is also used as a solubility enhancer for drugs such as indomethacin. D-Sorbitol (Sorbitol) is commonly used as a stabilizing excipient and/or isotonicity agent in both liquid and lyophilized parenteral protein formulations. D-Sorbitol (Sorbitol) is used in topical formulations as a humectant[2]. D-Sorbitol acts as a competitive inhibitor with a Ki of 5.5 mM against D-glucose, D-xylose, and D-ribose[3]. The hepatic clearance of D-sorbitol was proven to be a reliable parameter for evaluating the functional liver plasma flow[4]. In normal and under septic conditions, hepatic clearance of D-sorbitol either by bolus or a SS (steady-state) infusion is comparable[5].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03257436 Left Ventricular Dysfunction Not Applicable Recruiting July 2020 -
NCT00642148 Pulmonary Disease, Chronic Obs... 展开 >>tructive 收起 << Phase 2 Completed - -
NCT01726504 Constipation Phase 2 Completed - China, Beijing ... 展开 >> Guang'anmen Hospital of China Academy of Chinese Medical Sciences Beijing, Beijing, China, 100700 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.49mL

1.10mL

0.55mL

27.45mL

5.49mL

2.74mL

54.89mL

10.98mL

5.49mL
参考文献

[1]Teo G, Suzuki Y, et al. Silencing leaf sorbitol synthesis alters long-distance partitioning and apple fruit quality. Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18842-7.

[2]Dash RP, Srinivas NR, Babu RJ. Use of sorbitol as pharmaceutical excipient in the present day formulations - issues and challenges for drug absorption and bioavailability. Drug Dev Ind Pharm. 2019 Sep;45(9):1421-1429

[3]Sanchez S, Smiley KL. Properties of D-xylose isomerase from Streptomyces albus. Appl Microbiol. 1975 Jun;29(6):745-50

[4]Ballarè M, Avagnina P, Torchio M, Cavanna A, Aurucci PE, Niro AG, Molino G. D-sorbitol plasma disappearance rate: an index to evaluate changes in liver circulation. Ric Clin Lab. 1988 Oct-Dec;18(4):305-11

[5]van der Hoven B, van Pelt H, Swart EL, Bonthuis F, Tilanus HW, Bakker J, Gommers D. Noninvasive functional liver blood flow measurement: comparison between bolus dose and steady-state clearance of sorbitol in a small-rodent model. Am J Physiol Gastrointest Liver Physiol. 2010 Feb;298(2):G177-81