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GSK2795039

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Chemical Structure| 1415925-18-6 同义名 : -
CAS号 : 1415925-18-6
货号 : A251963
分子式 : C23H26N6O2S
纯度 : 99%+
分子量 : 450.557
MDL号 : MFCD30489720
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(233.05 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 GSK2795039 acts as an inhibitor of NADPH oxidase 2 (NOX2), showing potency with a mean pIC50 of 6 across various cell-free assays. It effectively reduces the production of reactive oxygen species (ROS) and consumption of NADPH[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.22mL

0.44mL

0.22mL

11.10mL

2.22mL

1.11mL

22.19mL

4.44mL

2.22mL
参考文献

[1]Hirano K, et al. Discovery of GSK2795039, a Novel Small Molecule NADPH Oxidase 2 Inhibitor. Antioxid Redox Signal. 2015 Aug 10;23(5):358-74.

[2]Yauger YJ, et al. Iron accentuated reactive oxygen species release by NADPH oxidase in activated microglia contributes to oxidative stress in vitro. J Neuroinflammation. 2019 Feb 18;16(1):41.