Mequinol

产品说明书

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Chemical Structure| 150-76-5 同义名 : 对羟基苯甲醚;对苯二酚单甲醚;4-甲氧基苯酚 ;4-Methoxyphenol
CAS号 : 150-76-5
货号 : A245207
分子式 : C7H8O2
纯度 : 98%
分子量 : 124.137
MDL号 : MFCD00002332
存储条件：

Pure form Sealed in dry,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(845.84 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(805.56 mM)
动物实验配方：
生物活性
描述 Mequinol, known as 4-Methoxyphenol, is recognized for its use in treating skin discoloration. As one of the active components derived from Mercurialis, it is mainly applied to alleviate various forms of hyperpigmentation[1]. In addition to its depigmenting properties, Mequinol serves as an antioxidant. It has been observed to have additive or synergistic effects on carcinogenesis when used alongside other phenolic antioxidants. Mequinol is also noted for promoting the production of hERα-dependent chaperones, indicating its potential estrogenic activity[1].[2].[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

8.06mL

1.61mL

0.81mL

40.28mL

8.06mL

4.03mL

80.56mL

16.11mL

8.06mL
参考文献

[1]Callender VD, et al. Postinflammatory hyperpigmentation: etiologic and therapeutic considerations. Am J Clin Dermatol. 2011 Apr 1;12(2):87-99.

[2]Hirose M, et al. Carcinogenicity of antioxidants BHA, caffeic acid, sesamol, 4-methoxyphenol and catechol at low doses, either alone or in combination, and modulation of their effects in a rat medium-term multi-organ carcinogenesis model. Carcinogenesis. 1998 Jan;19(1):207-12.

[3]Kita K, et al. Increase in the levels of chaperone proteins by exposure to beta-estradiol, bisphenol A and 4-methoxyphenol in human cells transfected with estrogen receptor alpha cDNA. Toxicol In Vitro. 2009 Jun;23(4):728-35.