产品说明书

	同义名 :	-
	CAS号 :	191744-13-5
	货号 :	A243424
	分子式 :	C13H13NO4
	纯度 :	99%+
	分子量 :	247.247
	MDL号 :	MFCD13248581
	存储条件：	粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

CX614 is a positively mutated modulator of AMPA receptors that enhances excitatory postsynaptic potentials (amplitude and duration) by blocking and slowing down inactivation of the response to glutamate and automatically evokes excitatory postsynaptic currents in neuronal cultures. CX614 can be used in the study of psychiatric disorders, such as depression[1][2].At a concentration of 100 μM, CX 614 enhances the apparent affinity of glutamate , increases glutamate-evoked inward currents, and enhances the peak glutamate response in HEK293 cells at 3.5 and 10 mM[1].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	4.04mL 0.81mL 0.40mL	20.22mL 4.04mL 2.02mL	40.45mL 8.09mL 4.04mL

参考文献
[1]Wei Dai, et al. The Impact and Mechanism of a Novel Allosteric AMPA Receptor Modulator LCX001 on Protection Against Respiratory Depression in Rodents. Front Pharmacol. 2019 Feb 19;10:105. [2]Eleni Dicou, et al. Positive allosteric modulators of AMPA receptors are neuroprotective against lesions induced by an NMDA agonist in neonatal mouse brain. Brain Res. 2003 Apr 25;970(1-2):221-5.