Carbinoxamine maleate salt
产品说明书
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同义名 : | Carbinoxamine (maleate);CarbinoxaMine Maleate;NSC 62362 |
| CAS号 : | 3505-38-2 | |
| 货号 : | A242556 | |
| 分子式 : | C20H23ClN2O5 | |
| 纯度 : | 99+% | |
| 分子量 : | 406.86 | |
| MDL号 : | MFCD00050923 | |
| 存储条件： |
Pure form Keep in dark place,Sealed in dry,Room Temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(258.07 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 50 mg/mL(122.89 mM)，配合低频超声助溶 |
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| 动物实验配方： |
PO 0.5% CMC-Na 40 mg/mL clear |
| 生物活性 | |||
|---|---|---|---|
| 靶点 |
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| 描述 | Carbinoxamine maleate is a histamine-H1 receptor blocking agent with antihistamine and anticholinergic properties[3]. Carbinoxamine maleate is an antihistamine drug with mild sedation effects, which is used to treat seasonal and perennial allergic rhinitis clinically[4]. The short half-life and bitter taste of carbinoxamine maleate (CAM) lead to poor compliance by pediatric patients who are being treated for allergic rhinitis. The homemade preparations had release behaviors similar to that of the reference in vitro and achieved sustained release in vivo. The low drug loading preparation had a higher relative bioavailability of 109% owing to its faster release and better dispersibility. The suspensions based on MCRCs (microencapsulated carbinoxamine-resin complexes) could be successfully applied to treating allergic rhinitis in children[5]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.46mL 0.49mL 0.25mL |
12.29mL 2.46mL 1.23mL |
24.58mL 4.92mL 2.46mL |
| 参考文献 |
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