Spinosin

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Chemical Structure| 72063-39-9 同义名 : Flavoayamenin
CAS号 : 72063-39-9
货号 : A241724
分子式 : C28H32O15
纯度 : 99%+
分子量 : 608.545
MDL号 : MFCD09754430
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(410.82 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Spinosin is a C-glycoside flavonoid isolated from the seeds of Zizyphus jujuba var. spinosa. Spinosin (10 or 20mg/kg, p.o.) significantly ameliorated scopolamine-induced cognitive impairment in these behavioral tasks with a prolonged latency time in the passive avoidance task, an increased percentage of spontaneous alternation in the Y-maze task and a lengthened swimming time in target quadrant in the Morris water maze task. In addition, spinosin significantly increased the expression levels of phosphorylated extracellular signal-regulated kinases and cAMP response element-binding proteins in the hippocampus[3]. Spinosin reduced Aβ1-42 production by activating the Nrf2/HO-1 pathway in N2a/WT (Wild type mouse Neuro-2a cells) and N2a/ APP695 cells[4]. Spinosin improves synaptic function in the AD hippocampus by regulating plasmin activity[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.64mL

0.33mL

0.16mL

8.22mL

1.64mL

0.82mL

16.43mL

3.29mL

1.64mL
参考文献

[1]Ko SY, Lee HE, et al. Spinosin, a C-Glucosylflavone, from Zizyphus jujuba var. spinosa Ameliorates Aβ1-42 Oligomer-Induced Memory Impairment in Mice. Biomol Ther (Seoul). 2015 Mar;23(2):156-64.

[2]Liu J, Zhai WM, et al. GABA and 5-HT systems are implicated in the anxiolytic-like effect of spinosin in mice. Pharmacol Biochem Behav. 2015 Jan;128:41-9.

[3]Jung IH, Lee HE, Park SJ, Ahn YJ, Kwon G, Woo H, Lee SY, Kim JS, Jo YW, Jang DS, Kang SS, Ryu JH. Ameliorating effect of spinosin, a C-glycoside flavonoid, on scopolamine-induced memory impairment in mice. Pharmacol Biochem Behav. 2014 May;120:88-94

[4]Zhang X, Wang J, Gong G, Ma R, Xu F, Yan T, Wu B, Jia Y. Spinosin Inhibits Aβ1-42 Production and Aggregation via Activating Nrf2/HO-1 Pathway. Biomol Ther (Seoul). 2020 May 1;28(3):259-266

[5]Cai M, Jung I, Kwon H, Cho E, Jeon J, Yun J, Lee YC, Kim DH, Ryu JH. Spinosin Attenuates Alzheimer's Disease-Associated Synaptic Dysfunction via Regulation of Plasmin Activity. Biomol Ther (Seoul). 2020 Mar 1;28(2):131-136