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CID5721353

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Chemical Structure| 301356-95-6 同义名 : BCL6 inhibitor
CAS号 : 301356-95-6
货号 : A240729
分子式 : C15H9BrN2O6S2
纯度 : 99%+
分子量 : 457.276
MDL号 : MFCD00366372
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(109.34 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 BCL6, a member of the BTB/POZ family of transcription factors, is the most frequently involved oncogene in diffuse large B cell lymphomas (DLBCLs) [2]. CID5721353 is an inhibitor of BCL6 with an IC50 value of 212 μM, which corresponds to a Ki of 147 μM PMID: 20385364. CID5721353 specifically disrupts BCL6 corepressor recruitment and can specifically reactivate BCL6 target genes in BCL6-dependent DLBCLs. It can also Selectively Kill BCL6-Dependent DLBCL Cells [2]. CID5721353 Suppresses Human DLBCL Xenografts in Mice. The levels of serum human β2-microglobulin (a surrogate marker of the xenograft burden) are significantly reduced by CID5721353 in the xenografted mice as compared with their respective controls for the OCI-Ly7 and SU-DHL6 xenografts (p=0.0117 and p=0.0004, respectively) [2].
作用机制 CID5721353 binds to a Pocket in the Lateral Groove of the BCL6BTB Domain [2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.19mL

0.44mL

0.22mL

10.93mL

2.19mL

1.09mL

21.87mL

4.37mL

2.19mL
参考文献

[1]US20120014979

[2] Cerchietti LC. A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo. Cancer Cell. 2010 Apr 13;17(4):400-11.