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SN 2

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Chemical Structure| 823218-99-1 同义名 : -
CAS号 : 823218-99-1
货号 : A239590
分子式 : C17H21NO
纯度 : 99%+
分子量 : 255.355
MDL号 : MFCD09266779
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(411.19 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 SN 2 is a potent activator of TRPML3 ion channel with an EC50 of 1.8 μM[1]. Beyond its role in ion channel modulation, SN 2 is also identified as an effective inhibitor of both Dengue virus 2 (DENV2) and Zika virus (ZIKV), marking it as a compound of interest for antiviral research[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.92mL

0.78mL

0.39mL

19.58mL

3.92mL

1.96mL

39.16mL

7.83mL

3.92mL
参考文献

[1]Grimm C, et al. Small molecule activators of TRPML3. Chem Biol. 2010 Feb 26;17(2):135-48.

[2]Zhiqiang Xia, et al. ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity. Antiviral Res. 2020 Aug 26;104922.