产品说明书
R406 free base
 |
同义名 : | R406;free base |
| CAS号 : | 841290-80-0 | |
| 货号 : | A233735 | |
| 分子式 : | C22H23FN6O5 | |
| 纯度 : | 98% | |
| 分子量 : | 470.454 | |
| MDL号 : | MFCD09970820 | |
| 存储条件： |
粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 25 mg/mL(53.14 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
1% DMSO+30% polyethylene glycol+1% Tween 80+water 30 mg/mL suspension |
| 生物活性 | |||
|---|---|---|---|
| 描述 | R406 is a potent Syk inhibitor with IC50 of 41 nM that strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT01725230 | Rheumatoid Arthritis | Phase 1 | Completed | - | United States, Kansas ... 展开 >> Research Site Overland Park, Kansas, United States 收起 << |
| NCT01208155 | Bioavailability ... 展开 >> Pharmacokinetics 收起 << | Phase 1 | Completed | - | United States, Kansas ... 展开 >> Research Site Overland Park, Kansas, United States 收起 << |
| NCT01245790 | Rheumatoid Arthritis ... 展开 >> Renal Impairment 收起 << | Phase 1 | Completed | - | United States, Florida ... 展开 >> Research Site Orlando, Florida, United States 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.13mL 0.43mL 0.21mL |
10.63mL 2.13mL 1.06mL |
21.26mL 4.25mL 2.13mL |
| 参考文献 |
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