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Sanguinarine chloride

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Chemical Structure| 5578-73-4 同义名 : 血根碱水合物 ;Sanguinarin chloride;Sanguinarium chloride;Sanguinarine (chloride);Pseudochelerythrine chloride
CAS号 : 5578-73-4
货号 : A229377
分子式 : C20H14ClNO4
纯度 : 99+%
分子量 : 367.783
MDL号 : MFCD00012126
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 3 mg/mL(8.16 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Sanguinarine chloride, a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine (SANG) could induce apoptosis in a dose- and time-dependent manner in UM-SCC-22B head and neck cancer cells. Moreover, SANG-induced apoptosis was associated with the generation of reactive oxygen species (ROS) and activation of JNK and NF-κB signal pathways[3]. Sanguinarine exhibits antitumor effects in epithelial ovarian cancer cells possible via regulating CASC2-EIF4A3 axis and/or inhibiting NF-κB signaling or PI3K/AKT/mTOR pathway[4]. Sanguinarine treatment (0.25, 0.5, 1, and 2 µM) of MC3T3-E1 cells significantly increased alkaline phosphatase (ALP) activity and the phoshporalyation of AMPKα, but did not affect cell proliferation. Sanguinarine treatment promoted bone tissue growth in an ovariectomized osteoporosis rat model[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.72mL

0.54mL

0.27mL

13.59mL

2.72mL

1.36mL

27.19mL

5.44mL

2.72mL
参考文献

[1]Rosen J, Landriscina A, et al. Characterization and assessment of nanoencapsulated sanguinarine chloride as a potential treatment for melanoma. J Drugs Dermatol. 2015 May;14(5):453-8.

[2]Afseth J, Rolla G. Clinical experiments with a mouthrinse containing sanguinarine chloride. Caries Res. 1987;21(3):285-8.

[3]Wang Y, Zhang B, Liu W, et al. Noninvasive bioluminescence imaging of the dynamics of sanguinarine induced apoptosis via activation of reactive oxygen species. Oncotarget. 2016;7(16):22355-22367

[4]Zhang S, Leng T, Zhang Q, Zhao Q, Nie X, Yang L. Sanguinarine inhibits epithelial ovarian cancer development via regulating long non-coding RNA CASC2-EIF4A3 axis and/or inhibiting NF-κB signaling or PI3K/AKT/mTOR pathway. Biomed Pharmacother. 2018;102:302-308

[5]Zhang F, Xie J, Wang G, Zhang G, Yang H. Anti-osteoporosis activity of Sanguinarine in preosteoblast MC3T3-E1 cells and an ovariectomized rat model. J Cell Physiol. 2018;233(6):4626-4633