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Theophylline-7-acetic Acid

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Chemical Structure| 652-37-9 同义名 : Acefylline;Theophyllineacetic acid;NSC 52996;Acephylline;Carboxymethyltheophylline;acetyloxytheophylline
CAS号 : 652-37-9
货号 : A229005
分子式 : C9H10N4O4
纯度 : 99+%
分子量 : 238.2
MDL号 : MFCD00022832
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(146.94 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Acefylline (Theophyllineacetic acid), a xanthine derivative, is an adenosine receptor antagonist. Theophylline (THEO) and its xanthinic derivatives inhibit lung phosphodiesterase (PDE) and block adenosine receptors in the induction of bronchodilatation[3]. As a PAD (Peptidylarginine deiminases) activator, acefylline will be useful to study the role of deimination and could be proposed to increase or correct the hydration of the cornified layers of the epidermis[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.20mL

0.84mL

0.42mL

20.99mL

4.20mL

2.10mL

41.98mL

8.40mL

4.20mL
参考文献

[1]Mechin MC, Cau L, et al. Acefylline activates filaggrin deimination by peptidylarginine deiminases in the upper epidermis. J Dermatol Sci. 2016 Feb;81(2):101-6.

[2]Voynikov Y, Valcheva V, et al. Theophylline-7-acetic acid derivatives with amino acids as anti-tuberculosis agents. Bioorg Med Chem Lett. 2014 Jul 15;24(14):3043-5.

[3]Ferretti C, Coppi G, Blengio M, Genazzani E. Inhibitory effect of theophylline, theophylline-7-acetic acid, ambroxol and ambroxol-theophylline-7-acetate on rat lung cAMP phosphodiesterase isoenzymes. Int J Tissue React. 1992;14(1):31-6

[4]Méchin MC, Cau L, Galliano MF, Daunes-Marion S, Poigny S, Vidaluc JL, Bessou-Touya S, Takahara H, Serre G, Duplan H, Simon M. Acefylline activates filaggrin deimination by peptidylarginine deiminases in the upper epidermis. J Dermatol Sci. 2016 Feb;81(2):101-6