Sulfathiazole

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Chemical Structure| 72-14-0 同义名 : -
CAS号 : 72-14-0
货号 : A227334
分子式 : C9H9N3O2S2
纯度 : 98+%
分子量 : 255.317
MDL号 : MFCD00005319
存储条件：

Pure form Keep in dark place,Inert atmosphere,Room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(979.18 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Sulfathiazole, an organosulfur compound, is used as a short-acting sulfonamide antibiotic.Recovery from spiked manure slurry samples is 64% for Sulfathiazole at pH 9. Sulfathiazole has acidity constant of pKa of 7.1and retention times (tR) of 7.8. S/N values for Sulfathiazole are above 100 at the 1 mg/kg level[3]. Sulfathiazole sorption to inorganic sorbents exhibited pronounced pH dependence consistent with sorbate speciation and sorbent charge properties.Sulfathiazole cations were most important for sorption to clay minerals [4]. The sorption of STZ (Sulfathiazole) on GMC-treated(giant Miscanthus) soils is greatly enhanced, mainly through the greater micropore surfaces, the abundance of hydrophilic functional groups over time, and π+-π electron donor-acceptor interaction at low pH[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.92mL

0.78mL

0.39mL

19.58mL

3.92mL

1.96mL

39.17mL

7.83mL

3.92mL
参考文献

[1]Perez S, Eichhorn P, Aga DS. Evaluating the biodegradability of sulfamethazine, sulfamethoxazole, sulfathiazole, and trimethoprim at different stages of sewage treatment. Environ Toxicol Chem. 2005 Jun;24(6):1361-7.

[2]Haller MY, Muller SR, et al. Quantification of veterinary antibiotics (sulfonamides and trimethoprim) in animal manure by liquid chromatography-mass spectrometry. J Chromatogr A. 2002 Apr 5;952(1-2):111-20.

[3]Haller MY, Müller SR, McArdell CS, Alder AC, Suter MJ. Quantification of veterinary antibiotics (sulfonamides and trimethoprim) in animal manure by liquid chromatography-mass spectrometry. J Chromatogr A. 2002;952(1-2):111–120

[4]Kahle M, Stamm C. Time and pH-dependent sorption of the veterinary antimicrobial sulfathiazole to clay minerals and ferrihydrite. Chemosphere. 2007;68(7):1224–1231

[5]Kim H, Kim J, Kim M, Hyun S, Moon DH. Sorption of sulfathiazole in the soil treated with giant Miscanthus-derived biochar: effect of biochar pyrolysis temperature, soil pH, and aging period. Environ Sci Pollut Res Int. 2018;25(26):25681–25689