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Cycloleucine

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Chemical Structure| 52-52-8 同义名 : 1-氨基环戊烷甲酸
CAS号 : 52-52-8
货号 : A224871
分子式 : C6H11NO2
纯度 : 98%
分子量 : 129.157
MDL号 : -
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 20 mg/mL(154.85 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Cycloleucine acts as a specific blocker of S-adenosyl-methionine dependent methylation processes and antagonizes the NMDA receptor-associated glycine receptor, evidenced by a Ki value of 600 μM. It also competitively inhibits ATP: L-methionine-S-adenosyl transferase in vitro, displaying anxiolytic and cytostatic effects[1].[2].[3].[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

7.74mL

1.55mL

0.77mL

38.71mL

7.74mL

3.87mL

77.43mL

15.49mL

7.74mL
参考文献

[1]Hood WF, et, al. 1-Aminocyclobutane-1-carboxylate (ACBC): a specific antagonist of the N-methyl-D-aspartate receptor coupled glycine receptor. Eur J Pharmacol. 1989 Feb 28;161(2-3):281-2.

[2]Caboche M, et, al. RNA methylation and control of eukaryotic RNA biosynthesis. Effects of cycloleucine, a specific inhibitor of methylation, on ribosomal RNA maturation. Eur J Biochem. 1977 Mar 15;74(1):19-29.

[3]Gargiulo API, et, al. Effects of Cycloleucine in the Nucleus Accumbens Septi on the Elevated plus Maze Test in Rats. Neuropsychobiology. 2020;79(3):191-197.

[4]Duś D, et, al. Cytostatic activity in vitro of cycloleucine, aspartic acid and glutamic acid phosphonic analogues. Arch Immunol Ther Exp (Warsz). 1980;28(3):433-8.

[5]Dimock K, et, al. Cycloleucine blocks 5'-terminal and internal methylations of avian sarcoma virus genome RNA. Biochemistry. 1978 Aug 22;17(17):3627-32.

[6]S Amor, et al. The effect of cycloleucine on SFV A7(74) infection in mice. Br J Exp Pathol. 1987 Apr;68(2):225-35.