产品说明书

Fludrocortisone acetate

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Chemical Structure| 514-36-3 同义名 : 9α-Fluorcortisol acetate;9α-Fludrocortisone acetate;U 4845;NSC 15186;9α-fluoro Hydrocortisone Acetate
CAS号 : 514-36-3
货号 : A198673
分子式 : C23H31FO6
纯度 : 98%
分子量 : 422.487
MDL号 : MFCD00864160
存储条件：

粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(118.35 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Fludrocortisone acetate is a synthetic mineralocorticoid, used to control the amount of sodium and fluids in your body. It is used to treat Addison's disease by decreasing the amount of sodium that is lost (excreted) in your urine, also used to increase blood pressure. Treatment with FCA (Fludrocortisone Acetate) produced dose-dependent (5, 10, and 25 mg/kg) increases in both magnitude and duration of water and sodium intake. Chronic elevation of water and saline intake was achieved with daily injections of FCA. Daily injection of FCA, when only 0.9% saline was available, produced a remarkably rapid increase in saline intake. A single injection of FCA stimulated brisk diuresis and natriuresis in fluid-restricted animals[3]. Administration of fludrocortisone resulted in a significant decrease in the UACR (urinary aldosterone to creatinine ratio) in healthy cats. Using the UACR for an oral fludrocortisone suppression test may be useful for the diagnosis of primary hyperaldosteronism in cats[4]. DOCP (desoxycorticosterone pivalate) treatment more effectively suppresses PRA (plasma renin activity) compared to FC (fludrocortisone acetate) in dogs with PH (primary hypoadrenocorticism) [5].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01398098 Colonoscopy Phase 2 Completed - France ... 展开 >> Cochin Hospital Paris, France, 75014 收起 <<
NCT01030874 Orthostatic Hypotension ... 展开 >> Falls 收起 << Not Applicable Completed - United States, Oregon ... 展开 >> VA Portland Health Care System, Portland, OR Portland, Oregon, United States, 97239 收起 <<
NCT00011778 Squamous Cell Carcinoma Phase 1 Completed - United States, Maryland ... 展开 >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.37mL

0.47mL

0.24mL

11.83mL

2.37mL

1.18mL

23.67mL

4.73mL

2.37mL
参考文献

[1]Rowe PC, Calkins H, et al. Fludrocortisone acetate to treat neurally mediated hypotension in chronic fatigue syndrome: a randomized controlled trial. JAMA. 2001 Jan 3;285(1):52-9.

[2]Wijdicks EF, Vermeulen M, et al. The effect of fludrocortisone acetate on plasma volume and natriuresis in patients with aneurysmal subarachnoid hemorrhage. Clin Neurol Neurosurg. 1988;90(3):209-14.

[3]Johnson RF, Beltz TG, Johnson AK, Thunhorst RL. Effects of fludrocortisone on water and sodium intake of C57BL/6 mice. Am J Physiol Regul Integr Comp Physiol. 2015 Aug 1;309(3):R247-54

[4]Djajadiningrat-Laanen SC, Galac S, Cammelbeeck SE, van Laar KJ, Boer P, Kooistra HS. Urinary aldosterone to creatinine ratio in cats before and after suppression with salt or fludrocortisone acetate. J Vet Intern Med. 2008 Nov-Dec;22(6):1283-8

[5]Baumstark ME, Nussberger J, Boretti FS, Baumstark MW, Riond B, Reusch CE, Sieber-Ruckstuhl NS. Use of plasma renin activity to monitor mineralocorticoid treatment in dogs with primary hypoadrenocorticism: desoxycorticosterone versus fludrocortisone. J Vet Intern Med. 2014 Sep-Oct;28(5):1471-8