产品说明书

9-Aminoacridine

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Chemical Structure| 90-45-9 同义名 : 吖啶-9-胺 ;Aminacrine
CAS号 : 90-45-9
货号 : A196593
分子式 : C13H10N2
纯度 : 98%
分子量 : 194.232
MDL号 : MFCD00037839
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(128.71 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 9-Aminoacridine, a fluorescent probe, is a pH indicator for quantitatively assessing transmembrane pH gradients, particularly in acidic environments. It possesses antimicrobial properties, effectively disrupting the proton motive force in K. pneumoniae by interacting with bacterial DNA. Additionally, 9-Aminoacridine acts as an inhibitor of HIV-1, blocking HIV LTR transcription in a manner highly dependent on the position and presence of its amino moiety. It also inhibits virus replication in HIV-1 infected cell lines and enhances the effectiveness of Rifampin in treating multidrug-resistant K. pneumoniae infections[1].[2].[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.15mL

1.03mL

0.51mL

25.74mL

5.15mL

2.57mL

51.48mL

10.30mL

5.15mL
参考文献

[1]S Grzesiek, et al. The 'delta pH'-probe 9-aminoacridine: response time, binding behaviour and dimerization at the membrane. Biochim Biophys Acta. 1988 Mar 3;938(3):411-24.

[2]Pengfei She, et al. Repurposing 9-Aminoacridine as an Adjuvant Enhances the Antimicrobial Effects of Rifampin against Multidrug-Resistant Klebsiella pneumonia. Microbiol Spectr. 2023 Jun 15;11(3):e0447422.

[3]Irene Guendel, et al. 9-Aminoacridine inhibition of HIV-1 Tat dependent transcription. Virol J. 2009 Jul 24:6:114.