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DOCK2-IN-1

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Chemical Structure| 4590-86-7 同义名 : -
CAS号 : 4590-86-7
货号 : A1964089
分子式 : C16H11ClN2O2
纯度 : 99%+
分子量 : 298.724
MDL号 : N/A
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(401.71 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 DOCK2-IN-1, analogous to CPYPP, functions as an inhibitor targeting the DOCK2 enzyme, with an IC50 of 19.1 μM. It engages the DOCK2 DHR-2 domain reversibly, impeding its catalytic function. This inhibitor effectively halts the activation of Rac, a GTPase, by both chemokine and antigen receptors in lymphocytes, thereby substantially diminishing chemotactic responses and T cell activation[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.35mL

0.67mL

0.33mL

16.74mL

3.35mL

1.67mL

33.48mL

6.70mL

3.35mL
参考文献

[1]Nishikimi A, et al. Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2. Chem Biol. 2012 Apr 20;19(4):488-97.