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BPDBA

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Chemical Structure| 312281-74-6 同义名 : -
CAS号 : 312281-74-6
货号 : A1958399
分子式 : C19H20Cl2N2O
纯度 : 98%
分子量 : 363.281
MDL号 : N/A
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(289.03 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 BPDBA is a selective and non-competitive inhibitor of the betaine/GABA transporter (BGT-1), with IC50s of 20 μM and 35 μM for human BGT-1 and mouse GAT2, respectively. BPDBA is predicted to have excellent oral absorption and blood-brain-barrier permeability properties [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.75mL

0.55mL

0.28mL

13.76mL

2.75mL

1.38mL

27.53mL

5.51mL

2.75mL
参考文献

[1]Kragholm B, et al. Discovery of a subtype selective inhibitor of the human betaine/GABA transporter 1 (BGT-1) with a non-competitive pharmacological profile. Biochem Pharmacol. 2013 Aug 15;86(4):521-8.