产品说明书

Zongertinib

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Chemical Structure| 2728667-27-2 同义名 : BI 1810631
CAS号 : 2728667-27-2
货号 : A1942329
分子式 : C29H29N9O2
纯度 : 98%
分子量 : 535.6
MDL号 : N/A
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(56.01 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Zongertinib (BI 1810631) is a potent and selective inhibitor of HER2 and EGFR tyrosine kinases, with IC50 values of 13 nM and 579 nM, respectively. It exhibits antitumor activity and holds promise for research in various solid tumors [1][2][3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.87mL

0.37mL

0.19mL

9.34mL

1.87mL

0.93mL

18.67mL

3.73mL

1.87mL
参考文献

[1]WHO Drug Informat ion - World Health Organization (WHO).

[2]Wilding Birgit, et al. Synthesis of diazino-pyrimidines as anticancer agents: World Intellectual Property Organization, WO2021213800. 2021-10-28.

[3]Li S, et al. Emerging Targeted Therapies in Advanced Non-Small-Cell Lung Cancer. Cancers (Basel). 2023 May 24;15(11):2899.