产品说明书

AS8351

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Chemical Structure| 796-42-9 同义名 : NSC51355;NCI 51355
CAS号 : 796-42-9
货号 : A1932733
分子式 : C17H13N3O2
纯度 : 99%+
分子量 : 291.304
MDL号 : MFCD00033110
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 145 mg/mL(497.76 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 AS8351, also known as NSC51355, is an inhibitor of KDM5B that promotes and maintains active chromatin configurations, aiding in the generation of cells resembling cardiomyocytes[1]. It intervenes in epigenetic alterations by vying with α-ketoglutarate (α-KG) to bind iron [Fe(II)], which is essential for the function of certain epigenetic enzymes, including JmjC domain-containing histone demethylases (JmjC-KDMs) that depend on α-KG and iron as cofactors[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.43mL

0.69mL

0.34mL

17.16mL

3.43mL

1.72mL

34.33mL

6.87mL

3.43mL
参考文献

[1]Liu K, et al. Chemical Modulation of Cell Fate in Stem Cell Therapeutics and Regenerative Medicine. Cell Chem Biol. 2016 Aug 18;23(8):893-916.

[2]Cao N, et al. Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science. 2016 Jun 3;352(6290):1216-20.