产品说明书

GRP78-IN-3

Print
Chemical Structure| 2707510-30-1 同义名 : -
CAS号 : 2707510-30-1
货号 : A1810519
分子式 : C17H18N4O2S
纯度 : 99%+
分子量 : 342.415
MDL号 : -
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 4 mg/mL(11.68 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 GRP78-IN-3 functions as a selective inhibitor of Grp78 (HSPA5) with an IC50 of 0.59 μM. It displays 7-fold selectivity for HspA5 over HspA9 (IC50 of 4.3 μM) and greater than 20-fold selectivity for HspA5 over HspA2 (IC50 of 13.9 μM) [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.92mL

0.58mL

0.29mL

14.60mL

2.92mL

1.46mL

29.20mL

5.84mL

2.92mL
参考文献

[1]Andrew J Ambrose, et al. Discovery and Development of a Selective Inhibitor of the ER Resident Chaperone Grp78. J Med Chem. 2022 Dec 14.