产品说明书

HJ-PI01

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Chemical Structure| 6192-43-4 同义名 : 10-Acetylphenoxazine
CAS号 : 6192-43-4
货号 : A1807234
分子式 : C14H11NO2
纯度 : 99%+
分子量 : 225.243
MDL号 : MFCD00093787
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(221.98 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 HJ-PI01 (10-Acetylphenoxazine) acts as an oral Pim-2 inhibitor, triggering apoptosis and autophagic death in cancer cells. It suppresses tumor development in MDA-MB-231 xenograft mice and is applicable for use in cancer research [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.44mL

0.89mL

0.44mL

22.20mL

4.44mL

2.22mL

44.40mL

8.88mL

4.44mL
参考文献

[1]Zhao YQ, et al. Characterization of HJ-PI01 as a novel Pim-2 inhibitor that induces apoptosis and autophagic cell death in triple-negative human breast cancer. Acta Pharmacol Sin. 2016 Sep;37(9):1237-50.