产品说明书

Propargyl-PEG3-acid

Print
Chemical Structure| 1347760-82-0 同义名 : -
CAS号 : 1347760-82-0
货号 : A179722
分子式 : C10H16O5
纯度 : 97%
分子量 : 216.231
MDL号 : MFCD22201521
存储条件:

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 : -
动物实验配方:
生物活性
描述 Propargyl-PEG3-acid is a non-cleavable linker for ADCs, consisting of a 3-unit PEG chain. It also serves as a PEG-based linker for PROTACs synthesis, enabling the formation of 6-OHDA-PEG3-yne, which includes 6-OHDA and Propargyl-PEG3-acid [1]. Propargyl-PEG3-acid serves as a click chemistry reagent, featuring an alkyne group capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with molecules containing azide groups.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.62mL

0.92mL

0.46mL

23.12mL

4.62mL

2.31mL

46.25mL

9.25mL

4.62mL

参考文献

[1]Farzam A, et al. A functionalized hydroxydopamine quinone links thiol modification to neuronal cell death. Redox Biol. 2020 Jan;28:101377.