Amantadine

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Chemical Structure| 768-94-5 同义名 : 金刚烷胺;1-金刚烷胺 ;1-Adamantanamine;1-Aminoadamantane;1-Adamantylamine
CAS号 : 768-94-5
货号 : A176786
分子式 : C10H17N
纯度 : 98%+
分子量 : 151.25
MDL号 : MFCD00074732
存储条件：

Pure form Keep in dark place,Inert atmosphere,Room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 9 mg/mL(59.5 mM)，配合低频超声，并调节pH至2，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Amantadine, known chemically as 1-Adamantanamine, is a potent orally active antiviral agent effective against influenza A viruses. It also blocks various ion channels, including NMDA and M2, and inhibits Coronavirus ion channels, showcasing its broad antiviral capabilities. Additionally, Amantadine possesses anti-orthopoxvirus and anticancer activities, making it applicable in Parkinson's disease, postoperative cognitive dysfunction (POCD), and COVID-19 research[1].[2].[3].[4].[5].[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

6.61mL

1.32mL

0.66mL

33.06mL

6.61mL

3.31mL

66.12mL

13.22mL

6.61mL
参考文献

[1]Suzuki H, et al. Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother. 2003;9(3):195-200.

[2]Hubsher G, et al. Amantadine: the journey from fighting flu to treating Parkinson disease. Neurology. 2012;78(14):1096-1099.

[3]Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57(1-2):41-52.

[4]Fink K, et al. Amantadine Inhibits SARS-CoV-2 In Vitro. Viruses. 2021 Mar 24;13(4):539.

[5]Zhang J, et al. Amantadine alleviates postoperative cognitive dysfunction possibly by increasing glial cell line-derived neurotrophic factor in rats. Anesthesiology. 2014 Oct;121(4):773-85.

[6]Lan Z, et al. Amantadine inhibits cellular proliferation and induces the apoptosis of hepatocellular cancer cells in vitro. Int J Mol Med. 2015;36(3):904-910.