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TP0472993

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Chemical Structure| 2126874-77-7 同义名 : -
CAS号 : 2126874-77-7
货号 : A1721473
分子式 : C16H20N4O2
纯度 : 98%
分子量 : 300.356
MDL号 : N/A
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(83.23 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 CYP4A11/CYP4F2-IN-2 acts as a potent, orally available inhibitor that targets both cytochrome P450 4A11 and CYP4F2 enzymes, displaying IC50 values of 140 nM and 40 nM, respectively. This dual inhibitor holds promise for studies related to kidney diseases[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.33mL

0.67mL

0.33mL

16.65mL

3.33mL

1.66mL

33.29mL

6.66mL

3.33mL
参考文献

[1]Kawamura M, et, al. Discovery of Novel Pyrazolylpyridine Derivatives for 20-Hydroxyeicosatetraenoic Acid Synthase Inhibitors with Selective CYP4A11/4F2 Inhibition. J Med Chem. 2022 Nov 10;65(21):14599-14613.

[2]Wunder F, et al. Characterization of the cellular activity of PDE 4 inhibitors using two novel PDE 4 reporter celllines. Mol Pharm. 2013 Oct 7;10(10):3697-705.