SET2

产品说明书

Print
Chemical Structure| 2313525-20-9 同义名 : -
CAS号 : 2313525-20-9
货号 : A1721084
分子式 : C17H21F3N4O2S
纯度 : 99%+
分子量 : 402.435
MDL号 : -
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(260.91 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 SET2 is a specific TRPV2 antagonist with an IC50 of 0.46 μM. It inhibits the TRP channel and attenuates the migration of prostate cancer cells. Additionally, SET2 diminishes the elevation of cytoplasmic calcium induced by lysophosphatidic acid (LPA), an activator of TRPV2[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.48mL

0.50mL

0.25mL

12.42mL

2.48mL

1.24mL

24.85mL

4.97mL

2.48mL
参考文献

[1]Chai H, et al. Structure-Based Discovery of a Subtype-Selective Inhibitor Targeting a Transient Receptor Potential Vanilloid Channel. J Med Chem. 2019 Feb 14;62(3):1373-1384.