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Methyl Stearate

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Chemical Structure| 112-61-8 同义名 : 硬脂酸甲酯 ;Stearic acid methyl ester;Methyl octadecanoate;C18:0 Methyl ester
CAS号 : 112-61-8
货号 : A171330
分子式 : C19H38O2
纯度 : 99+%
分子量 : 298.504
MDL号 : MFCD00009005
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 12 mg/mL(40.2 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Stearic acid methyl ester (SAME) is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils. SAME can enhance MSCs (Mesenchymal stem cells) migration ability mainly through the Vav1/ROCK2 signaling pathway, which could contribute to the accelerated cartilage regeneration[1]. PAME (palmitic acid methyl ester), SAME, and Solutol HS15 provide robust neuroprotection in both paradigms of ischemia[2]. Stearic acid inhibited the colony-forming ability of 4 out of 5 rat and two human tumour continuous cell lines in vitro. Using a model of rat mammary carcinoma induced by nitroso-methyl urea (NMU) the subcutaneous injection of stearic acid at weekly intervals prevented tumour development in 5 to 10 rats. Stearic acid inhibits tumour development in rats[3]. Stearic acid significantly induced CD11c expression in monocytes through activation of the nuclear retinoid acid receptor[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.35mL

0.67mL

0.34mL

16.75mL

3.35mL

1.68mL

33.50mL

6.70mL

3.35mL
参考文献

[1]Liu Y, Xu L, Hu L, Chen D, Yu L, Li X, Chen H, Zhu J, Chen C, Luo Y, Wang B, Li G. Stearic acid methyl ester promotes migration of mesenchymal stem cells and accelerates cartilage defect repair. J Orthop Translat. 2019 Oct 23;22:81-91

[2]Lin HW, Saul I, Gresia VL, Neumann JT, Dave KR, Perez-Pinzon MA. Fatty acid methyl esters and Solutol HS 15 confer neuroprotection after focal and global cerebral ischemia. Transl Stroke Res. 2014 Feb;5(1):109-17

[3]Habib NA, Wood CB, Apostolov K, Barker W, Hershman MJ, Aslam M, Heinemann D, Fermor B, Williamson RC, Jenkins WE, et al. Stearic acid and carcinogenesis. Br J Cancer. 1987 Oct;56(4):455-8

[4]Zeng J, Zhang Y, Hao J, Sun Y, Liu S, Bernlohr DA, Sauter ER, Cleary MP, Suttles J, Li B. Stearic Acid Induces CD11c Expression in Proinflammatory Macrophages via Epidermal Fatty Acid Binding Protein. J Immunol. 2018 May 15;200(10):3407-3419