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BAY-1436032

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Chemical Structure| 1803274-65-8 同义名 : -
CAS号 : 1803274-65-8
货号 : A169849
分子式 : C26H30F3N3O3
纯度 : 99%+
分子量 : 489.53
MDL号 : MFCD30533279
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(245.13 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 BAY-1436032, identified as a comprehensive mutant IDH1 inhibitor, curtails the production of intracellular (R)-2-hydroxyglutarate (R-2HG) in mouse hematopoietic cells harboring IDH1R132H or IDH1R132C mutations, with IC50s of 60 and 45 nM, respectively. It does not affect R-2HG levels in cells expressing IDH2R140Q and IDH2R172K up to a concentration of 10 μM. A 0.1 μM concentration of BAY-1436032 inhibits colony growth by 50%, while up to 100 μM does not hinder the colony growth of AML cells with wild-type IDH1. BAY-1436032 notably induces myelomonocytic differentiation in myeloid progenitors[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.04mL

0.41mL

0.20mL

10.21mL

2.04mL

1.02mL

20.43mL

4.09mL

2.04mL
参考文献

[1]Chaturvedi A, et al. Pan-mutant-IDH1 inhibitor BAY1436032 is highly effective against human IDH1 mutant acute myeloid leukemia in vivo. Leukemia. 2017 Oct;31(10):2020-2028.