产品说明书

hCAI/II-IN-6

Print
Chemical Structure| 694466-00-7 同义名 : -
CAS号 : 694466-00-7
货号 : A1678235
分子式 : C19H24N4O3S
纯度 : 99%+
分子量 : 388.484
MDL号 : N/A
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(643.53 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 hCAI/II-IN-6, an orally active human carbonic anhydrase (CA) inhibitor, selectively inhibits hCA II and hCA VII isoforms with Ki values of 220, 4.9, 6.5, and ＞50000 nM for hCA I, hCA II, hCA VII, and hCA XII, respectively. It exhibits anticonvulsant and anti maximal electroshock (MES) activities in vivo, suitable for epilepsy research [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.57mL

0.51mL

0.26mL

12.87mL

2.57mL

1.29mL

25.74mL

5.15mL

2.57mL
参考文献

[1]Mishra CB, et al. Discovery of Benzenesulfonamides with Potent Human Carbonic Anhydrase Inhibitory and Effective Anticonvulsant Action: Design, Synthesis, and Pharmacological Assessment. J Med Chem. 2017 Mar 23;60(6):2456-2469.