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AMPK-IN-3

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Chemical Structure| 2417674-27-0 同义名 : -
CAS号 : 2417674-27-0
货号 : A1673691
分子式 : C25H33N5O3
纯度 : 98%
分子量 : 451.561
MDL号 : MFCD34676664
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 110 mg/mL(243.6 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 AMPK-IN-3 is an effective and specific inhibitor of AMPK, exhibiting IC50 values of 60.7 nM for AMPK (α2), 107 nM for AMPK (α1), and 3820 nM for KDR. Its inhibition of AMPK does not compromise the viability of K562 cells nor does it induce notable cytotoxic effects. This makes AMPK-IN-3 suitable for cancer research[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.21mL

0.44mL

0.22mL

11.07mL

2.21mL

1.11mL

22.15mL

4.43mL

2.21mL
参考文献

[1]Matheson CJ, et al. Substituted oxindol-3-ylidenes as AMP-activated protein kinase (AMPK) inhibitors. Eur J Med Chem. 2020 Jul 1;197:112316.

[2]Chaponis D, et al. Lonafarnib (SCH66336) improves the activity of temozolomide and radiation for orthotopic malignant gliomas. J Neurooncol. 2011 Aug;104(1):179-89.