产品说明书

NFATc1-IN-1

Print
Chemical Structure| 1912422-56-0 同义名 : -
CAS号 : 1912422-56-0
货号 : A1671418
分子式 : C13H8F2INO2
纯度 : 99%+
分子量 : 375.1
MDL号 : -
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(319.91 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 NFATc1-IN-1 is a potent inhibitor of RANKL-induced osteoclast formation, demonstrating an IC50 of 1.57 μM. It exhibits anti-osteoclastogenic effects by reducing RANKL-induced NFATc1 nuclear translocation and is suitable for research into osteoclastic diseases[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.67mL

0.53mL

0.27mL

13.33mL

2.67mL

1.33mL

26.66mL

5.33mL

2.67mL
参考文献

[1]Chen CL, et al. Design, synthesis and SARs of novel salicylanilides as potent inhibitors of RANKL-induced osteoclastogenesis and bone resorption. Eur J Med Chem. 2016 Jul 19;117:70-84.